| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-HERPUD1 (1-240) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
HERPUD1 |
| Gene ID: |
9709 |
| Uniprot ID: |
HERP1_HUMAN |
| Immunogen Region: |
1-240 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human HERPUD1 (NP_055500.1). |
| Immunogen Sequence: |
MESETEPEPVTLLVKSPNQR HRDLELSGDRGWSVGHLKAH LSRVYPERPRPEDQRLIYSG KLLLDHQCLRDLLPKQEKRH VLHLVCNVKSPSKMPEINAK VAESTEEPAGSNRGQYPEDS SSDGLRQREVLRNLSSPGWE NISRPEAAQQAFQGLGPGFS GYTPYGWLQLSWFQQIYARQ YYMQYLAATAASGAFVPPPS AQEIPVVSAPAPAPIHNQFP AENQPANQNAAPQVVVNPG |
| Tissue Specificity | Widely expressed.in the brain, expression seems to be restricted to neurons and vascular smooth muscle cells. Present in activated microglia in senile plaques in the brain of patients with Alzheimer disease. |
| Function | Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated amyloid-beta protein 40 generation. Binds to ubiquilins and this interaction is required for efficient degradation of CD3D via the ERAD pathway. |
| Protein Name | Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 ProteinMethyl MethanesulfonateMmf-Inducible Fragment Protein 1 |
| Database Links | Reactome: R-HSA-380994 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Homocysteine-Responsive Endoplasmic Reticulum-Resident Ubiquitin-Like Domain Member 1 Protein antibodyAnti-Methyl Methanesulfonate antibodyAnti-Mmf-Inducible Fragment Protein 1 antibodyAnti-HERPUD1 antibodyAnti-HERP antibodyAnti-KIAA0025 antibodyAnti-MIF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
