| Tissue Specificity | Highest expression in liver and to a lesser extent in heart and brain. Low levels in lung, tonsils, salivary gland, trachea, prostate gland, adrenal gland and thyroid gland. Secreted into the urine and blood. Expressed by hepatocytes. |
| Function | Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin/SLC40A1, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes. Has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker against S.epidermidis, S.aureus and group b streptococcus bacteria. Active against the fungus C.albicans. No activity against P.aeruginosa. |
| Protein Name | HepcidinLiver-Expressed Antimicrobial Peptide 1Leap-1Putative Liver Tumor RegressorPltr Cleaved Into - Hepcidin-25Hepc25 - Hepcidin-20Hepc20 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Hepcidin antibodyAnti-Liver-Expressed Antimicrobial Peptide 1 antibodyAnti-Leap-1 antibodyAnti-Putative Liver Tumor Regressor antibodyAnti-Pltr Cleaved Into - Hepcidin-25 antibodyAnti-Hepc25 - Hepcidin-20 antibodyAnti-Hepc20 antibodyAnti-HAMP antibodyAnti-HEPC antibodyAnti-LEAP1 antibodyAnti-UNQ487 antibodyAnti-PRO1003 antibody |
Information sourced from Uniprot.org
