| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HDAC6 |
| Gene ID: | 10013 |
| Uniprot ID: | HDAC6_HUMAN |
| Immunogen Region: | 836-1104 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 836-1104 of human HDAC6 (NP_006035.2). |
| Immunogen Sequence: | VMKVEDREGPSSSKLVTKKA PQPAKPRLAERMTTREKKVL EAGMGKVTSASFGEESTPGQ TNSETAVVALTQDQPSEAAT GGATLAQTISEAAIGGAMLG QTTSEEAVGGATPDQTTSEE TVGGAILDQTTSEDAVGGAT LGQTTSEEAVGGATLAQTTS EAAMEGATLDQTTSEEAPGG TELIQTPLASSTDHQTPPTS PVQGTTPQISPSTLIGSLRT LELGSESQGASESQAPGEE |
| Post Translational Modifications | Phosphorylated by AURKA.phosphorylation increases HDAC6-mediated deacetylation of alpha-tubulin and subsequent disassembly of cilia. Ubiquitinated. Its polyubiquitination however does not lead to its degradation. Sumoylated in vitro. |
| Function | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. In addition to histones, deacetylates other proteins, such as CTTN, tubulin and SQSTM1. Plays a central role in microtubule-dependent cell motility by mediating deacetylation of tubulin. Required for cilia disassembly.via deacetylation of alpha-tubulin. Promotes deacetylation of CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Promotes odontoblast differentiation following IPO7-mediated nuclear import and subsequent repression of RUNX2 expression. In addition to its protein deacetylase activity, plays a key role in the degradation of misfolded proteins: when misfolded proteins are too abundant to be degraded by the chaperone refolding system and the ubiquitin-proteasome, mediates the transport of misfolded proteins to a cytoplasmic juxtanuclear structure called aggresome. Probably acts as an adapter that recognizes polyubiquitinated misfolded proteins and target them to the aggresome, facilitating their clearance by autophagy. |
| Protein Name | Histone Deacetylase 6 Hd6 Protein Deacetylase Hdac6 Tubulin-Lysine Deacetylase Hdac6 |
| Database Links | Reactome: R-HSA-2122947 Reactome: R-HSA-2644606 Reactome: R-HSA-2894862 Reactome: R-HSA-3371511 Reactome: R-HSA-350054 Reactome: R-HSA-5617833 Reactome: R-HSA-8878166 Reactome: R-HSA-8940973 Reactome: R-HSA-9613829 Reactome: R-HSA-9615710 Reactome: R-HSA-9646399 |
| Cellular Localisation | Cytoplasm Cytoskeleton Nucleus Perikaryon Cell Projection Dendrite Axon Cilium Microtubule Organizing Center Centrosome Cilium Basal Body It Is Mainly Cytoplasmic Where It Is Associated With Microtubules |
| Alternative Antibody Names | Anti-Histone Deacetylase 6 antibody Anti-Hd6 antibody Anti-Protein Deacetylase Hdac6 antibody Anti-Tubulin-Lysine Deacetylase Hdac6 antibody Anti-HDAC6 antibody Anti-KIAA0901 antibody Anti-JM21 antibody |
Information sourced from Uniprot.org