| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | HAUS8 |
| Gene ID: | 93323 |
| Uniprot ID: | HAUS8_HUMAN |
| Immunogen Region: | 166-410 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 166-410 of human HAUS8 (NP_219485.1). |
| Immunogen Sequence: | NLAEFERRAEKNLLIMCKEK EKLQKKAHELKRRLLLSQRK RELADVLDAQIEMLSPFEAV ATRFKEQYRTFATALDTTRH ELPVRSIHLEGDGQQLLDAL QHELVTTQRLLGELDVGDSE ENVQVLDLLSELKDVTAKKD LELRRSFAQVLELSAEASKE AALANQEVWEETQGMAPPSR WYFNQDSACRESGGAPKNTP LSEDDNPGASSAPAQATFIS PSEDFSSSSQAEVPPSLSR |
| Function | Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex. |
| Protein Name | Haus Augmin-Like Complex Subunit 8Hec1/Ndc80-Interacting Centrosome-Associated Protein 1Sarcoma Antigen Ny-Sar-48 |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-5620912Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindleSpindle PoleDuring InterphasePrimarily Cytoplasmic And Associates With Centrosomes And With The Mitotic SpindlesPreferentially At The Spindle Pole VicinityDuring Anaphase And TelophaseAdditionally Associates With The Spindle Midzone And MidbodyRespectivelyLocalizes To Mitotic Spindle Microtubules |
| Alternative Antibody Names | Anti-Haus Augmin-Like Complex Subunit 8 antibodyAnti-Hec1/Ndc80-Interacting Centrosome-Associated Protein 1 antibodyAnti-Sarcoma Antigen Ny-Sar-48 antibodyAnti-HAUS8 antibodyAnti-HICE1 antibody |
Information sourced from Uniprot.org