| Tissue Specificity | Expressed predominantly in the gastrointestinal (GI) tract and in the skin at a lower level. In the GI tract, the expression is highly restricted to the esophagus and forestomach. |
| Post Translational Modifications | Cleavage by bacterial SpeB relieves autoinhibition by releasing the N-terminal moiety (Gasdermin-A, N-terminal) that initiates pyroptosis. Palmitoylated. |
| Function | Gasdermin-A: This form constitutes the precursor of the pore-forming protein and acts as a sensor of bacterial infection: upon infection, specifically cleaved by bacterial effector protein SpeB in epithelial cells, releasing the N-terminal moiety (Gasdermin-A, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Gasdermin-A, N-terminal: Pore-forming protein that causes membrane permeabilization and pyroptosis. Released upon cleavage by bacterial effector protein SpeB, and binds to membrane inner leaflet lipids. Homooligomerizes within the membrane and forms pores of 10-15 nanometers (nm) of inner diameter, triggering pyroptosis. Pyroptosis triggers the elimination of the infected skin cell, depriving the pathogen of its protective niche, while inducing an inflammatory response. This ultimately prevents bacterial penetration of the epithelial barrier and a subsequent systemic dissemination of the pathogen. Binds to cardiolipin and other acidic phospholipids, such as phosphatidylserine, which mediate its targeting to the inner leaflet membrane. |
| Protein Name | Gasdermin-AGasdermin-1Gasdermin-A1 Cleaved Into - Gasdermin-A - N-TerminalGsdma-Nt - Gasdermin-A - C-TerminalGsdma-Ct |
| Cellular Localisation | Gasdermin-A: CytoplasmPerinuclear RegionCytoplasmCytosolGasdermin-AN-Terminal: Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Gasdermin-A antibodyAnti-Gasdermin-1 antibodyAnti-Gasdermin-A1 Cleaved Into - Gasdermin-A - N-Terminal antibodyAnti-Gsdma-Nt - Gasdermin-A - C-Terminal antibodyAnti-Gsdma-Ct antibodyAnti-Gsdma antibodyAnti-Gsdm antibodyAnti-Gsdm1 antibodyAnti-Gsdma1 antibody |
Information sourced from Uniprot.org
