| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR32 |
| Gene ID: | 2854 |
| Uniprot ID: | GPR32_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GPR32 (NP_001497.1). |
| Immunogen Sequence: | MNGVSEGTRGCSDRQPGVLT RDRSCSRKMNSSGCLSEEVG SLRPLTVVILSASIVVGVLG NGLVLWMTVFRMARTVSTVC FFHLALADFMLSLSLPIAMY |
| Tissue Specificity | Expressed in resting primary human macrophages. |
| Function | G-protein coupled receptor that binds to several ligands including resolvin D1 (RvD1) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. In macrophages, enhances the RvD1-stimulated phagocytic and clearance functions. Macrophages migrate less toward different chemoattractant stimuli but phagocytose more microbial particles. Prevents the increase in Ca(2+) and activation of ERK1/2 used by histamine and its H1 receptor subtype to induce goblet cell secretion by activating PKC and GRK2 to counter-regulate the histamine receptor. |
| Protein Name | Probable G-Protein Coupled Receptor 32 |
| Database Links | Reactome: R-HSA-418555 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Probable G-Protein Coupled Receptor 32 antibodyAnti-GPR32 antibody |
Information sourced from Uniprot.org
