Anti-GPR143 antibody (151-200 aa) (STJ93339)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GPR143 at the amino acid range 151-200
General Information
| Short Description | Rabbit polyclonal anti-G-protein coupled receptor 143 (151-200 aa) for use in IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPR143 |
| Gene ID | 4935 |
| Uniprot ID | GP143_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GPR143 at the amino acid range 151-200 |
| Immunogen Region | 151-200 aa |
| Specificity | GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein. |
Additional Info
| Post Translational Modifications | Glycosylated. Phosphorylated. |
| Function | Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane.this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. |
| Protein Name | G-Protein Coupled Receptor 143Ocular Albinism Type 1 Protein |
| Database Links | Reactome: R-HSA-375280Reactome: R-HSA-416476Reactome: R-HSA-9824585 |
| Cellular Localisation | Melanosome MembraneMulti-Pass Membrane ProteinLysosome MembraneApical Cell MembraneDistributed Throughout The Endo-Melanosomal System But Most Of Endogenous Protein Is Localized In Unpigmented Stage Ii MelanosomesIts Expression On The Apical Cell Membrane Is Sensitive To Tyrosine |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 143 antibodyAnti-Ocular Albinism Type 1 Protein antibodyAnti-GPR143 antibodyAnti-OA1 antibody |
Information sourced from Uniprot.org