• Immunofluorescence analysis of LOVO cells, using GPR143 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-GPR143 antibody (151-200 aa) (STJ93339)

SKU:
STJ93339

$62.10 - $305.10
Current Stock:
Host: Rabbit
Applications: IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-G-protein coupled receptor 143 (151-200 aa) is suitable for use in Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPR143
Gene ID: 4935
Uniprot ID: GP143_HUMAN
Immunogen Region: 151-200 aa
Specificity: GPR143 Polyclonal Antibody detects endogenous levels of GPR143 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human GPR143 at the amino acid range 151-200
Post Translational Modifications Glycosylated. Phosphorylated.
Function Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane.this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Also plays a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.
Protein Name G-Protein Coupled Receptor 143
Ocular Albinism Type 1 Protein
Database Links Reactome: R-HSA-375280
Reactome: R-HSA-416476
Cellular Localisation Melanosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Apical Cell Membrane
Distributed Throughout The Endo-Melanosomal System But Most Of Endogenous Protein Is Localized In Unpigmented Stage Ii Melanosomes
Its Expression On The Apical Cell Membrane Is Sensitive To Tyrosine
Alternative Antibody Names Anti-G-Protein Coupled Receptor 143 antibody
Anti-Ocular Albinism Type 1 Protein antibody
Anti-GPR143 antibody
Anti-OA1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance