Western blot analysis of extracts of HepG2 cells, using GNAT2 antibody (STJ112390) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 15s.

Anti-GNAT2 antibody (1-220) (STJ112390)

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STJ112390
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:2000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GNAT2
Gene ID: 2780
Uniprot ID: GNAT2_HUMAN
Immunogen Region: 1-220
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human GNAT2 (NP_005263.1).
Immunogen Sequence: MGSGASAEDKELAKRSKELE KKLQEDADKEAKTVKLLLLG AGESGKSTIVKQMKIIHQDG YSPEECLEFKAIIYGNVLQS ILAIIRAMTTLGIDYAEPSC ADDGRQLNNLADSIEEGTMP PELVEVIRRLWKDGGVQACF ERAAEYQLNDSASYYLNQLE RITDPEYLPSEQDVLRSRVK TTGIIETKFSVKDLNFRMFD VGGQRSERKKWIHCFEGVTC
Tissue Specificity Retinal rod outer segment.
Function Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Transducin is an amplifier and one of the transducers of a visual impulse that performs the coupling between rhodopsin and cGMP-phosphodiesterase.
Protein Name Guanine Nucleotide-Binding Protein G(T Subunit Alpha-2
Transducin Alpha-2 Chain
Database Links Reactome: R-HSA-4086398
Reactome: R-HSA-418594
Cellular Localisation Cell Projection
Cilium
Photoreceptor Outer Segment
Photoreceptor Inner Segment
Localizes Mainly In The Outer Segment In The Dark-Adapted State
Whereas Is Translocated To The Inner Part Of The Photoreceptors In The Light-Adapted State
During Dark-Adapted Conditions
In The Presence Of Unc119 Mislocalizes From The Outer Segment To The Inner Part Of Rod Photoreceptors Which Leads To Decreased Photoreceptor Damage Caused By Light
Alternative Antibody Names Anti-Guanine Nucleotide-Binding Protein G(T Subunit Alpha-2 antibody
Anti-Transducin Alpha-2 Chain antibody
Anti-GNAT2 antibody
Anti-GNATC antibody

Information sourced from Uniprot.org

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