| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
GLRX2 |
| Gene ID: |
51022 |
| Uniprot ID: |
GLRX2_HUMAN |
| Immunogen Region: |
1-124 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-124 of human GLRX2 (NP_001230328.1). |
| Immunogen Sequence: |
MESNTSSSLENLATAPVNQI QETISDNCVVIFSKTSCSYC TMAKKLFHDMNVNYKVVELD LLEYGNQFQDALYKMTGERT VPRIFVNGTFIGGATDTHRL HKEGKLLPLVHQCYLKKSKR KEFQ |
| Tissue Specificity | Widely expressed. Expressed in brain, heart, skeletal muscle, colon, thymus, spleen, kidney, liver, small intestine, placenta and lung. Not expressed in peripheral blood leukocytes. |
| Function | Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. |
| Protein Name | Glutaredoxin-2 - Mitochondrial |
| Cellular Localisation | Isoform 1: MitochondrionIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Glutaredoxin-2 - Mitochondrial antibodyAnti-GLRX2 antibodyAnti-GRX2 antibodyAnti-CGI-133 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
