| Host: |
Rabbit |
| Applications: |
WB/IF/ICC/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
NIPSNAP2 |
| Gene ID: |
2631 |
| Uniprot ID: |
NIPS2_HUMAN |
| Immunogen Region: |
1-50 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-50 of human GBAS (NP_001474.1). |
| Immunogen Sequence: |
MAARVLRARGAAWAGGLLQR AAPCSLLPRLRTWTSSSNRS REDSWLKSLF |
| Tissue Specificity | Widely expressed. Most abundant in heart and skeletal muscle. |
| Function | Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria. Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2). |
| Protein Name | Protein Nipsnap Homolog 2Nipsnap2Glioblastoma-Amplified Sequence |
| Database Links | Reactome: R-HSA-9013407Reactome: R-HSA-9013409 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Protein Nipsnap Homolog 2 antibodyAnti-Nipsnap2 antibodyAnti-Glioblastoma-Amplified Sequence antibodyAnti-NIPSNAP2 antibodyAnti-GBAS antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
