| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GABRQ |
| Gene ID: | 55879 |
| Uniprot ID: | GBRT_HUMAN |
| Immunogen Region: | 350-600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 350-600 of human GABRQ (NP_061028.3). |
| Immunogen Sequence: | NYLFYSRGPRRQPRRHRRPR RVIARYRYQQVVVGNVQDGL INVEDGVSSLPITPAQAPLA SPESLGSLTSTSEQAQLATS ESLSPLTSLSGQAPLATGES LSDLPSTSEQARHSYGVRFN GFQADDSIIPTEIRNRVEAH GHGVTHDHEDSNESLSSDER HGHGPSGKPMLHHGEKGVQE AGWDLDDNNDKSDCLAIKEQ FKCDTNSTWGLNDDELMAHG QEKDSSSESEDSCPPSPGC |
| Tissue Specificity | Expressed in brain. |
| Function | Theta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit ThetaGaba(A Receptor Subunit ThetaGabaar Subunit Theta |
| Database Links | Reactome: R-HSA-1236394Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Theta antibodyAnti-Gaba(A Receptor Subunit Theta antibodyAnti-Gabaar Subunit Theta antibodyAnti-GABRQ antibody |
Information sourced from Uniprot.org