| Post Translational Modifications | Hyperphosphorylated during mitosis by CDK1 and, to a lower extent, CDK2. Phosphorylation at Ser-373 and Ser-428 affects stability by promoting degradation. |
| Function | Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis and autophagy. Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context. Together with FOXK1, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen. Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4. Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate. Together with FOXK1, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins. In addition to the 5'-GTAAACA-3' DNA motif, also binds the 5'-TGANTCA-3' palindromic DNA motif, and co-associates with JUN/AP-1 to activate transcription. Also able to bind to a minimal DNA heteroduplex containing a G/T-mismatch with 5'-TRTG/TNB-3' sequence. Binds to NFAT-like motifs (purine-rich) in the IL2 promoter. Positively regulates WNT/beta-catenin signaling by translocating DVL proteins into the nucleus. Also binds to HIV-1 long terminal repeat. May be involved in both positive and negative regulation of important viral and cellular promoter elements. Accessory component of the polycomb repressive deubiquitinase (PR-DUB) complex.recruits the PR-DUB complex to specific FOXK2-bound genes. |
| Protein Name | Forkhead Box Protein K2G/T-Mismatch Specific Binding ProteinNgtbpInterleukin Enhancer-Binding Factor 1 |
| Database Links | Reactome: R-HSA-5689603 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Forkhead Box Protein K2 antibodyAnti-G/T-Mismatch Specific Binding Protein antibodyAnti-Ngtbp antibodyAnti-Interleukin Enhancer-Binding Factor 1 antibodyAnti-FOXK2 antibodyAnti-ILF antibodyAnti-ILF1 antibody |
Information sourced from Uniprot.org
