| Tissue Specificity | Expressed by cytolytic cells including NK cells, effector and effector-memory CD8(+) T-cells, and a subset of NKT cells (at protein level). Also expressed in gamma delta T cells and in a rare subset of effector CD4(+) T-cells (at protein level). Expressed in spleen, skin, peripheral blood leukocytes, liver, lung, bone marrow, small intestine and placenta. Expression among T-cells is greatly expanded in HIV-1 infected individuals, and includes not only effector and effector-memory CD8(+) T-cells but also populations of CD4(+) T-cells. Expression among CD8(+) T-cells and NK cells is expanded in individuals with chronic lymphocytic leukemia (CLL) but is reduced in PBMCs from patients with acute (AML), chronic myeloid leukemia (CML) and non-Hodgkin's lymphoma. Expression is higher in PBMCs and/or CD3(+) cells of patients with autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) and idiopathic thrombocytopenia purpura (ITP). In contrast, expression in CD3(+) cells from patients with lupus anticoagulans (LA) is higher. |
| Post Translational Modifications | Phosphorylated on Tyr residues. Tyrosine phosphorylation induces association with phosphatase PTPN11, PTPN6, INPP5D, INPPL1 and GRB2. |
| Function | Acts as a MHC class II receptor. When stimulated on its own, does not play a role in cytokine production or the release of cytotoxic granules by NK cells and cytotoxic CD8(+) T cells. Does not act as an Fc receptor. |
| Protein Name | Fc Receptor-Like Protein 6Fcr-Like Protein 6Fcrl6Fc Receptor Homolog 6Fcrh6Ifgp6 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Fc Receptor-Like Protein 6 antibodyAnti-Fcr-Like Protein 6 antibodyAnti-Fcrl6 antibodyAnti-Fc Receptor Homolog 6 antibodyAnti-Fcrh6 antibodyAnti-Ifgp6 antibodyAnti-FCRL6 antibodyAnti-FCRH6 antibody |
Information sourced from Uniprot.org
