| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FBLIM1 (180-272) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FBLIM1 |
| Gene ID: |
54751 |
| Uniprot ID: |
FBLI1_HUMAN |
| Immunogen Region: |
180-272 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-272 of human FBLIM1 (NP_060026.2). |
| Immunogen Sequence: |
TDICAFCHKTVSPRELAVEA MKRQYHAQCFTCRTCRRQLA GQSFYQKDGRPLCEPCYQDT LERCGKCGEVVRDHIIRALG QAFHPSCFTCVTC |
| Tissue Specificity | Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. |
| Function | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. |
| Protein Name | Filamin-Binding Lim Protein 1Fblp-1MigfilinMitogen-Inducible 2-Interacting ProteinMig2-Interacting Protein |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeletonStress FiberAssociated With Actin Stress Fiber At Cell-Ecm Focal Adhesion SitesIsoform 1 And Isoform 3 Are Recruited And Localized At Actin Stress Fibers And Clustered At Cell-Emc Adhesion Sites Through Interaction With Fermt2Isoform 2 Is Localized At Actin Stress Fibers |
| Alternative Antibody Names | Anti-Filamin-Binding Lim Protein 1 antibodyAnti-Fblp-1 antibodyAnti-Migfilin antibodyAnti-Mitogen-Inducible 2-Interacting Protein antibodyAnti-Mig2-Interacting Protein antibodyAnti-FBLIM1 antibodyAnti-FBLP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
