| Tissue Specificity | Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. |
| Function | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. |
| Protein Name | Filamin-Binding Lim Protein 1Fblp-1MigfilinMitogen-Inducible 2-Interacting ProteinMig2-Interacting Protein |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeletonStress FiberAssociated With Actin Stress Fiber At Cell-Ecm Focal Adhesion SitesIsoform 1 And Isoform 3 Are Recruited And Localized At Actin Stress Fibers And Clustered At Cell-Emc Adhesion Sites Through Interaction With Fermt2Isoform 2 Is Localized At Actin Stress Fibers |
| Alternative Antibody Names | Anti-Filamin-Binding Lim Protein 1 antibodyAnti-Fblp-1 antibodyAnti-Migfilin antibodyAnti-Mitogen-Inducible 2-Interacting Protein antibodyAnti-Mig2-Interacting Protein antibodyAnti-FBLIM1 antibodyAnti-FBLP1 antibody |
Information sourced from Uniprot.org
