| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-40-kDa huntingtin-associated protein (33-83 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | F8A1.F8A2.F8A3 |
| Gene ID: | 474383/474384/8263 |
| Uniprot ID: | HAP40_HUMAN |
| Immunogen Region: | 33-83 aa |
| Specificity: | This antibody detects endogenous levels of F8I2 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human F8I2 at the amino acid range 33-83 |
| Function | RAB5A effector molecule that is involved in vesicular trafficking of early endosomes. Mediates the recruitment of HTT by RAB5A onto early endosomes. The HTT-F8A1/F8A2/F8A3-RAB5A complex stimulates early endosomal interaction with actin filaments and inhibits interaction with microtubules, leading to the reduction of endosome motility. |
| Protein Name | 40-Kda Huntingtin-Associated ProteinHap40Cpg Island ProteinFactor Viii Intron 22 Protein |
| Cellular Localisation | CytoplasmNucleusEarly EndosomeNuclear BodyDiffuse Presence In The Cytoplasm And Accumulation In The NucleusIn Absence Of HttF8a1/F8a2/F8a3 Is Concentred In CytoplasmColocalized With Htt In EndosomesIn Neuron Found In Intranuclear StructuresThe Intranuclear Rodlets (Inrs)Also Known As Rodlets Of RoncoroniIn Association With Ubiquitin |
| Alternative Antibody Names | Anti-40-Kda Huntingtin-Associated Protein antibodyAnti-Hap40 antibodyAnti-Cpg Island Protein antibodyAnti-Factor Viii Intron 22 Protein antibodyAnti-F8A1.F8A2.F8A3 antibody |
Information sourced from Uniprot.org