| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:3000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | EVC |
| Gene ID: | 2121 |
| Uniprot ID: | EVC_HUMAN |
| Immunogen Region: | 743-992 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 743-992 of human EVC (NP_714928.1). |
| Immunogen Sequence: | AIGQALLVHARNAATKSRAK DRDDFKRTLMEAAVESVYVT SAGVSRLVQAYYQQIGRIME DHEERKLQHLKTLQGERMEN YKLRKKQELSNPSSGSRTAG GAHETSQAVHQRMLSQQKRF LAQFPVHQQMRLHAQQQQAG VMDLLEAQLETQLQEAEQNF ISELAALARVPLAESKLLPA KRGLLEKPLRTKRKKPLPQE RGDLGVPNNEDLASGDQTSG SLSSKRLSQQESEAGDSGN |
| Tissue Specificity | Found in the developing vertebral bodies, ribs, upper and lower limbs, heart, kidney, lung. |
| Function | Component of the EvC complex that positively regulates ciliary Hedgehog (Hh) signaling. Involved in endochondral growth and skeletal development. |
| Protein Name | Evc Complex Member EvcDwf-1Ellis-Van Creveld Syndrome Protein |
| Database Links | Reactome: R-HSA-5632684Reactome: R-HSA-5635838 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmCytoskeletonCilium Basal BodyCell ProjectionCiliumCilium MembraneEvc2 Is Required For The Localization Of Evc At The Base Of Primary CiliaThe Evc Complex Localizes At The Base Of Cilia In The Evc Zone Of Primary Cilia In A Efcab7-Dependent Manner |
| Alternative Antibody Names | Anti-Evc Complex Member Evc antibodyAnti-Dwf-1 antibodyAnti-Ellis-Van Creveld Syndrome Protein antibodyAnti-EVC antibody |
Information sourced from Uniprot.org