| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | EPG5 |
| Gene ID: | 57724 |
| Uniprot ID: | EPG5_HUMAN |
| Immunogen Region: | 819-947 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 819-947 of human EPG5 (NP_066015.2). |
| Immunogen Sequence: | VGRELLGTITAVHPEIISVL LDRVQETIDQVGMVSLYLFK ELPLYLWQPSASEIAVIRDW LLNYNLTVVKNKLACVILEG LNWGFAKQATLHLDQAVHAE VALMVLEAYQKYLAQKPYAG ILSESMKQV |
| Function | Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located. |
| Protein Name | Ectopic P Granules Protein 5 Homolog |
| Cellular Localisation | CytoplasmPerinuclear RegionLysosome |
| Alternative Antibody Names | Anti-Ectopic P Granules Protein 5 Homolog antibodyAnti-EPG5 antibodyAnti-KIAA1632 antibody |
Information sourced from Uniprot.org