| Tissue Specificity | Found in the sera of cancer patients with a wide variety of cancers including breast, prostate, lung and ovarian cancers, leukemias, and lymphomas. Not found in the serum of healthy volunteers or patients with disorders other than cancer. Probably shed into serum by cancer cells. Found on the cell borders of renal, kidney and ovarian carcinomas but not on the borders of surrounding non-cancerous stromal cells. |
| Post Translational Modifications | Glycosylated. |
| Function | May be involved in cell growth. Probably acts as a terminal oxidase of plasma electron transport from cytosolic NAD(P)H via hydroquinones to acceptors at the cell surface. Hydroquinone oxidase activity alternates with a protein disulfide-thiol interchange/oxidoreductase activity which may control physical membrane displacements associated with vesicle budding or cell enlargement. The activities oscillate with a period length of 22 minutes and play a role in control of the ultradian cellular biological clock. |
| Protein Name | Ecto-Nox Disulfide-Thiol Exchanger 2Apk1 AntigenCytosolic Ovarian Carcinoma Antigen 1Tumor-Associated Hydroquinone OxidaseTnox Includes - Hydroquinone Nadh Oxidase - Protein Disulfide-Thiol Oxidoreductase |
| Cellular Localisation | Cell MembraneSecretedExtracellular SpaceExtracellular And Plasma Membrane-Associated |
| Alternative Antibody Names | Anti-Ecto-Nox Disulfide-Thiol Exchanger 2 antibodyAnti-Apk1 Antigen antibodyAnti-Cytosolic Ovarian Carcinoma Antigen 1 antibodyAnti-Tumor-Associated Hydroquinone Oxidase antibodyAnti-Tnox Includes - Hydroquinone Nadh Oxidase - Protein Disulfide-Thiol Oxidoreductase antibodyAnti-ENOX2 antibodyAnti-COVA1 antibody |
Information sourced from Uniprot.org
