| Post Translational Modifications | Myristoylation regulates subcellular location, and is necessary for activation of JNK. |
| Function | Dual specificity phosphatase.can dephosphorylate both phosphotyrosine and phosphoserine or phosphothreonine residues. Activates the JNK signaling pathway. Inhibits T-cell receptor signaling and T-cell mediated immune responses, acting, at least in part, by inducing degradation of E3 ubiquitin ligase UBR2. Dephosphorylates and thereby induces 'Lys-48'-linked ubiquitination of UBR2, leading to proteasomal degradation of UBR2. Dephosphorylates and thereby inactivates tyrosine kinase LCK. Inhibits UBR2-mediated 'Lys-63'-linked ubiquitination of LCK. May play a role in B-cell receptor (BCR) signaling and B-cell function. |
| Protein Name | Dual Specificity Protein Phosphatase 22Jnk Pathway Associated PhosphataseJkapJnk-Stimulatory Phosphatase-1Jsp-1Low Molecular Weight Dual Specificity Phosphatase 2Lmw-Dsp2Mitogen-Activated Protein Kinase Phosphatase XMap Kinase Phosphatase XMkp-X |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 22 antibodyAnti-Jnk Pathway Associated Phosphatase antibodyAnti-Jkap antibodyAnti-Jnk-Stimulatory Phosphatase-1 antibodyAnti-Jsp-1 antibodyAnti-Low Molecular Weight Dual Specificity Phosphatase 2 antibodyAnti-Lmw-Dsp2 antibodyAnti-Mitogen-Activated Protein Kinase Phosphatase X antibodyAnti-Map Kinase Phosphatase X antibodyAnti-Mkp-X antibodyAnti-DUSP22 antibodyAnti-JSP1 antibodyAnti-LMWDSP2 antibodyAnti-MKPX antibody |
Information sourced from Uniprot.org
