| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DEF6 (60-330) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DEF6 |
| Gene ID: |
50619 |
| Uniprot ID: |
DEFI6_HUMAN |
| Immunogen Region: |
60-330 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 60-330 of human DEF6 (NP_071330.3). |
| Immunogen Sequence: |
DGPVSSQGYMPYLNKYILDK VEEGAFVKEHFDELCWTLTA KKNYRADSNGNSMLSNQDAF RLWCLFNFLSEDKYPLIMVP DEVEYLLKKVLSSMSLEVSL GELEELLAQEAQVAQTTGGL SVWQFLELFNSGRCLRGVGR DTLSMAIHEVYQELIQDVLK QGYLWKRGHLRRNWAERWFQ LQPSCLCYFGSEECKEKRGI IPLDAHCCVEVLPDRDGKRC MFCVKTANRTYEMSASDTR |
| Tissue Specificity | Broadly expressed in the immune system. Highly expressed in T cells. |
| Post Translational Modifications | Tyrosine-phosphorylated by tyrosine-protein kinase LCK in response to T-cell activation. |
| Function | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Involved in immune homeostasis by ensuring proper trafficking and availability of T-cell regulator CTLA-4 at T-cell surface. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. |
| Protein Name | Differentially Expressed In Fdcp 6 HomologDef-6Irf4-Binding Protein |
| Database Links | Reactome: R-HSA-8980692Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmCell MembraneNucleusCytoskeletonPerinuclear RegionCell ProjectionFilopodiumRecruited To The Plasma Membrane Upon Binding Phosphatidylinositol 345-TrisphosphateBinds To Actin Filaments |
| Alternative Antibody Names | Anti-Differentially Expressed In Fdcp 6 Homolog antibodyAnti-Def-6 antibodyAnti-Irf4-Binding Protein antibodyAnti-DEF6 antibodyAnti-IBP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
