| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP2A6 (91-300) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2A6 |
| Gene ID: |
1548 |
| Uniprot ID: |
CP2A6_HUMAN |
| Immunogen Region: |
91-300 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 91-300 of human CYP2A6 (NP_000753.3). |
| Immunogen Sequence: |
LVDQAEEFSGRGEQATFDWV FKGYGVVFSNGERAKQLRRF SIATLRDFGVGKRGIEERIQ EEAGFLIDALRGTGGANIDP TFFLSRTVSNVISSIVFGDR FDYKDKEFLSLLRMMLGIFQ FTSTSTGQLYEMFSSVMKHL PGPQQQAFQLLQGLEDFIAK KVEHNQRTLDPNSPRDFIDS FLIRMQEEEKNPNTEFYLKN LVMTTLNLFI |
| Tissue Specificity | Liver. |
| Function | Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. |
| Protein Name | Cytochrome P450 2a61 -4-Cineole 2-Exo-MonooxygenaseCypiia6Coumarin 7-HydroxylaseCytochrome P450 Iia3Cytochrome P450(I |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2a6 antibodyAnti-1 -4-Cineole 2-Exo-Monooxygenase antibodyAnti-Cypiia6 antibodyAnti-Coumarin 7-Hydroxylase antibodyAnti-Cytochrome P450 Iia3 antibodyAnti-Cytochrome P450(I antibodyAnti-CYP2A6 antibodyAnti-CYP2A3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
