| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CYP2A6 |
| Gene ID: | 1548 |
| Uniprot ID: | CP2A6_HUMAN |
| Immunogen Region: | 215-494 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 215-494 of human CYP2A6 (NP_000753.3). |
| Immunogen Sequence: | STGQLYEMFSSVMKHLPGPQ QQAFQLLQGLEDFIAKKVEH NQRTLDPNSPRDFIDSFLIR MQEEEKNPNTEFYLKNLVMT TLNLFIGGTETVSTTLRYGF LLLMKHPEVEAKVHEEIDRV IGKNRQPKFEDRAKMPYMEA VIHEIQRFGDVIPMSLARRV KKDTKFRDFFLPKGTEVYPM LGSVLRDPSFFSNPQDFNPQ HFLNEKGQFKKSDAFVPFSI GKRNCFGEGLARMELFLFF |
| Tissue Specificity | Liver. |
| Function | Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity. |
| Protein Name | Cytochrome P450 2a61 -4-Cineole 2-Exo-MonooxygenaseCypiia6Coumarin 7-HydroxylaseCytochrome P450 Iia3Cytochrome P450(I |
| Database Links | Reactome: R-HSA-211981Reactome: R-HSA-211999 |
| Cellular Localisation | Endoplasmic Reticulum MembranePeripheral Membrane ProteinMicrosome Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 2a6 antibodyAnti-1 -4-Cineole 2-Exo-Monooxygenase antibodyAnti-Cypiia6 antibodyAnti-Coumarin 7-Hydroxylase antibodyAnti-Cytochrome P450 Iia3 antibodyAnti-Cytochrome P450(I antibodyAnti-CYP2A6 antibodyAnti-CYP2A3 antibody |
Information sourced from Uniprot.org