| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Cystinosin (234-284 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CTNS |
| Gene ID: | 1497 |
| Uniprot ID: | CTNS_HUMAN |
| Immunogen Region: | 234-284 aa |
| Specificity: | This antibody detects endogenous levels of CTNS at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human CTNS at the amino acid range 234-284 |
| Function | Cystine/H(+) symporter that mediates export of cystine, the oxidized dimer of cysteine, from lysosomes. Plays an important role in melanin synthesis by catalyzing cystine export from melanosomes, possibly by inhibiting pheomelanin synthesis. In addition to cystine export, also acts as a positive regulator of mTORC1 signaling in kidney proximal tubular cells, via interactions with components of the v-ATPase and Ragulator complexes. Also involved in small GTPase-regulated vesicle trafficking and lysosomal localization of LAMP2A, independently of cystine transporter activity. |
| Protein Name | Cystinosin |
| Database Links | Reactome: R-HSA-425393Reactome: R-HSA-5223345 |
| Cellular Localisation | Isoform 1: Lysosome MembraneMulti-Pass Membrane ProteinMelanosome MembraneAp-3 Complex Is Required For Localization To The LysosomeIsoform 2: Lysosome MembraneCell Membrane |
| Alternative Antibody Names | Anti-Cystinosin antibodyAnti-CTNS antibody |
Information sourced from Uniprot.org