| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Casein kinase I isoform gamma-2 (10-59 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CSNK1G2 |
| Gene ID: |
1455 |
| Uniprot ID: |
KC1G2_HUMAN |
| Immunogen Region: |
10-59 aa |
| Specificity: |
Casein Kinase I Gamma 2 Polyclonal Antibody detects endogenous levels of Casein Kinase I Gamma 2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CKI-gamma2 at the amino acid range 10-59 |
| Post Translational Modifications | Autophosphorylated. Phosphorylated by aPKC which promotes dissociation from the cell cortex. |
| Function | Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis. Triggers PER1 proteasomal degradation probably through phosphorylation. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. Involved in regulation of reactive oxygen species (ROS) levels. |
| Protein Name | Casein Kinase I Isoform Gamma-2Cki-Gamma 2 |
| Database Links | Reactome: R-HSA-1660661Reactome: R-HSA-4641262 |
| Cellular Localisation | CytoplasmCell Cortex |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Gamma-2 antibodyAnti-Cki-Gamma 2 antibodyAnti-CSNK1G2 antibodyAnti-CK1G2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
