Anti-COL17A1 antibody (1300-1400) (STJ118789)

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STJ118789

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Host: Rabbit
Applications: WB
Reactivity: Human/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-COL17A1 (1300-1400) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: COL17A1
Gene ID: 1308
Uniprot ID: COHA1_HUMAN
Immunogen Region: 1300-1400
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human Collagen XVII/Collagen XVII/COL17A1 (NP_000485.3).
Immunogen Sequence: SVRRGSSYSSSMSTGGGGAG SLGAGGAFGEAAGDRGPYGT DIGPGGGYGAAAEGGMYAGN GGLLGADFAGDLDYNELAVR VSESMQRQGLLQGMAYTVQG P
Tissue Specificity Detected in skin. In the cornea, it is detected in the epithelial basement membrane, the epithelial cells, and at a lower level in stromal cells (at protein level). Stratified squamous epithelia. Found in hemidesmosomes. Expressed in cornea, oral mucosa, esophagus, intestine, kidney collecting ducts, ureter, bladder, urethra and thymus but is absent in lung, blood vessels, skeletal muscle and nerves.
Post Translational Modifications The intracellular/endo domain is disulfide-linked. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. The ectodomain is shedded from the surface of keratinocytes resulting in a 120-kDa soluble form, also named as 120 kDa linear IgA disease antigen. The shedding is mediated by membrane-bound metalloproteases. This cleavage is inhibited by phosphorylation at Ser-544.
Function May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. The 120 kDa linear IgA disease antigen is an anchoring filament component involved in dermal-epidermal cohesion. Is the target of linear IgA bullous dermatosis autoantibodies.
Protein Name Collagen Alpha-1(Xvii Chain
180 Kda Bullous Pemphigoid Antigen 2
Bullous Pemphigoid Antigen 2 Cleaved Into - 120 Kda Linear Iga Disease Antigen
120 Kda Linear Iga Dermatosis Antigen
Linear Iga Disease Antigen 1
Lad-1 - 97 Kda Linear Iga Disease Antigen
97 Kda Linear Iga Bullous Dermatosis Antigen
97 Kda Lad Antigen
97-Lad
Linear Iga Bullous Disease Antigen Of 97 Kda
Labd97
Database Links Reactome: R-HSA-1442490
Reactome: R-HSA-1650814
Reactome: R-HSA-198933
Reactome: R-HSA-2022090
Reactome: R-HSA-446107
Reactome: R-HSA-8948216
Cellular Localisation Cell Junction
Hemidesmosome
Membrane
Single-Pass Type Ii Membrane Protein
Localized Along The Plasma Membrane Of The Hemidesmosome
120 Kda Linear Iga Disease Antigen: Secreted
Extracellular Space
Extracellular Matrix
Basement Membrane
Exclusively Localized To Anchoring Filaments
Localized To The Epidermal Side Of Split Skin
97 Kda Linear Iga Disease Antigen: Secreted
Localized In The Lamina Lucida Beneath The Hemidesmosomes
Alternative Antibody Names Anti-Collagen Alpha-1(Xvii Chain antibody
Anti-180 Kda Bullous Pemphigoid Antigen 2 antibody
Anti-Bullous Pemphigoid Antigen 2 Cleaved Into - 120 Kda Linear Iga Disease Antigen antibody
Anti-120 Kda Linear Iga Dermatosis Antigen antibody
Anti-Linear Iga Disease Antigen 1 antibody
Anti-Lad-1 - 97 Kda Linear Iga Disease Antigen antibody
Anti-97 Kda Linear Iga Bullous Dermatosis Antigen antibody
Anti-97 Kda Lad Antigen antibody
Anti-97-Lad antibody
Anti-Linear Iga Bullous Disease Antigen Of 97 Kda antibody
Anti-Labd97 antibody
Anti-COL17A1 antibody
Anti-BP180 antibody
Anti-BPAG2 antibody

Information sourced from Uniprot.org

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