Anti-CNMD antibody (75-334 aa) (STJ11105237)

SKU:
STJ11105237
£112.50 - £524.50
Processing The item has been added

Host: Rabbit
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CNMD
Gene ID: 11061
Uniprot ID: CNMD_HUMAN
Immunogen Region: 75-334 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 75-334 of human CNMD. (NP_008946.1).
Immunogen Sequence: VHYTMSINGKLQDGSMEIDA GNNLETFKMGSGAEEAIAVN DFQNGITGIRFAGGEKCYIK AQVKARIPEVGAVTKQSISS KLEGKIMPVKYEENSLIWVA VDQPVKDNSFLSSKVLELCG DLPIFWLKPTYPKEIQRERR EVVRKIVPTTTKRPHSGPRS NPGAGRLNNETRPSVQEDSQ AFNPDNPYHQQEGESMTFDP RLDHEGICCIECRRSYTHCQ KICEPLGGYYPWPYNYQGC
Tissue Specificity Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma.
Post Translational Modifications After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein.
Function Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
Protein Name Leukocyte Cell-Derived Chemotaxin 1
Chondromodulin Cleaved Into - Chondrosurfactant Protein
Ch-Sp - Chondromodulin-1
Chondromodulin-I
Chm-I
Cellular Localisation Chondromodulin-1: Secreted
Extracellular Space
Extracellular Matrix
Accumulated In The Inter-Territorial Matrix Of Cartilage
Chondrosurfactant Protein: Endomembrane System
Single-Pass Membrane Protein
Alternative Antibody Names Anti-Leukocyte Cell-Derived Chemotaxin 1 antibody
Anti-Chondromodulin Cleaved Into - Chondrosurfactant Protein antibody
Anti-Ch-Sp - Chondromodulin-1 antibody
Anti-Chondromodulin-I antibody
Anti-Chm-I antibody
Anti-CNMD antibody
Anti-CHMI antibody
Anti-LECT1 antibody
Anti-MYETS1 antibody

Information sourced from Uniprot.org