| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Can insert into membranes and form non-selective ion channels almost equally permeable to Na(+), K(+) and Cl(-). Required for normal hearing. It is necessary for the formation of stereocilia in the inner ear and normal development of the organ of Corti. May play a role in the regulation of transepithelial ion absorption and secretion. Is required for the development and/or maintenance of the proper glomerular endothelial cell and podocyte architecture. Plays a role in formation of the lens suture in the eye, which is important for normal optical properties of the lens. |
| Protein Name | Chloride Intracellular Channel Protein 5Glutaredoxin-Like Oxidoreductase Clic5 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Isoform 1: CytoplasmCytoskeletonCytoplasmCell CortexMembraneSingle-Pass Membrane ProteinApical Cell MembraneMitochondrionCell ProjectionStereociliumAssociates With The Cortical Actin CytoskeletonLocalizes To The Apical Region Of Cochlear Hair CellsAt The Base Of The Actin-Rich Hair BundleColocalizes With Podocalyxin At The Apical Cell Membrane In Renal GlomeruliMay Localize To The Centrosome In Lens Epithelial CellsExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainIsoform 2: Golgi ApparatusMicrotubule Organizing CenterCentrosomeColocalizes With Akap9 At The Golgi Apparatus As Well AsTo A Lesser ExtentThe Centrosome |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 5 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic5 antibodyAnti-CLIC5 antibody |
Information sourced from Uniprot.org
