Western blot analysis of lysates from Hela cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-CLEC12B antibody (111-161 aa) (STJ194169)

SKU:
STJ194169
€60.00 - €315.00
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-C-type lectin domain family 12 member B (111-161 aa) is suitable for use in Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CLEC12B
Gene ID: 387837
Uniprot ID: CL12B_HUMAN
Immunogen Region: 111-161 aa
Specificity: This antibody detects endogenous levels of CL12B at Human/Mouse
Immunogen: Synthesized peptide derived from the human CL12B at the amino acid range 111-161
Post Translational Modifications N-glycosylated.
Function Inhibitory receptor postulated to negatively regulate immune and non-immune functions. Upon phosphorylation, recruits SH2 domain-containing PTPN6 and PTPN11 phosphatases to its ITIM motif and antagonizes activation signals. Although it inhibits KLRK1/NKG2D-mediated signaling, it does not bind known ligands of KLRK1/NKG2D and therefore is not its inhibitory counterpart. May limit activation of myeloid cell subsets in response to infection or tissue inflammation. May protect target cells against natural killer cell-mediated lysis. May negatively regulate cell cycle and differentiation of melanocytes via inactivation of STAT3.
Protein Name C-Type Lectin Domain Family 12 Member B
Macrophage Antigen H
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-C-Type Lectin Domain Family 12 Member B antibody
Anti-Macrophage Antigen H antibody
Anti-CLEC12B antibody
Anti-UNQ5782 antibody
Anti-PRO16089 antibody

Information sourced from Uniprot.org

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