STJ70721 (1µg/ml) staining of Human Duodenum lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-CLCA1 antibody (Internal) (STJ70721)

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STJ70721-100
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Goat polyclonal antibody anti-CLCA1 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:16000.
WB: Experiments gave bands at approx 80kDa and 30kDa in Human Duodenum lysates. These bands correspond to earlier findings in literature with different antibodies (Gruber et al, Genomics.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: CLCA1
Gene ID: 1179
Uniprot ID: CLCA1_HUMAN
Immunogen Region: Internal
Accession Number: NP_001276.1
Specificity: No cross-reactivity expected with CLCA2 and 3.
Immunogen Sequence: TVTSKTNKDTSK
Post Translational Modifications Glycosylated. The 125-kDa product is autoproteolytically processed by the metalloprotease domain and yields to two cell-surface-associated subunits, a 90-kDa protein and a group of 37- to 41-kDa proteins. The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity.
Function May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
Protein Name Calcium-Activated Chloride Channel Regulator 1
Calcium-Activated Chloride Channel Family Member 1
Hclca1
Calcium-Activated Chloride Channel Protein 1
Cacc-1
Hcacc-1
Database Links Reactome: R-HSA-2672351
Cellular Localisation Secreted
Extracellular Space
Cell Membrane
Peripheral Membrane Protein
Extracellular Side
Protein That Remains Attached To The Plasma Membrane Appeared To Be Predominantly Localized To Microvilli
Alternative Antibody Names Anti-Calcium-Activated Chloride Channel Regulator 1 antibody
Anti-Calcium-Activated Chloride Channel Family Member 1 antibody
Anti-Hclca1 antibody
Anti-Calcium-Activated Chloride Channel Protein 1 antibody
Anti-Cacc-1 antibody
Anti-Hcacc-1 antibody
Anti-CLCA1 antibody
Anti-CACC1 antibody

Information sourced from Uniprot.org

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