| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-MHC class II transactivator (706-755 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 ELISA 1:10000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CIITA |
| Gene ID: | 4261 |
| Uniprot ID: | C2TA_HUMAN |
| Immunogen Region: | 706-755 aa |
| Specificity: | CIITA Polyclonal Antibody detects endogenous levels of CIITA protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human CIITA at the amino acid range 706-755 |
| Function | Essential for transcriptional activity of the HLA class II promoter.activation is via the proximal promoter. Does not bind DNA. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both PubMed:8402893, PubMed:7749984,. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. Also mediates enhanced MHC class I transcription.the promoter element requirements for CIITA-mediated transcription are distinct from those of constitutive MHC class I transcription, and CIITA can functionally replace TAF1 at these genes. Activates CD74 transcription. Exhibits intrinsic GTP-stimulated acetyltransferase activity. Exhibits serine/threonine protein kinase activity: can phosphorylate the TFIID component TAF7, the RAP74 subunit of the general transcription factor TFIIF, histone H2B at 'Ser-37' and other histones (in vitro). Has antiviral activity against Ebola virus and coronaviruses, including SARS-CoV-2. Induces resistance by up-regulation of the p41 isoform of CD74, which blocks cathepsin-mediated cleavage of viral glycoproteins, thereby preventing viral fusion. Isoform 3: Exhibits dominant-negative suppression of MHC class II gene expression. |
| Protein Name | Mhc Class Ii Transactivator Ciita |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Nucleus Pml Body Recruited To Pml Body By Pml |
| Alternative Antibody Names | Anti-Mhc Class Ii Transactivator antibody Anti-Ciita antibody Anti-CIITA antibody Anti-MHC2TA antibody |
Information sourced from Uniprot.org