| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHST14 (180-280) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHST14 |
| Gene ID: |
113189 |
| Uniprot ID: |
CHSTE_HUMAN |
| Immunogen Region: |
180-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-280 of human CHST14 (NP_569735.1). |
| Immunogen Sequence: |
LKMDHRSDLVFLADLRPEEI RYRLQHYFKFLFVREPLERL LSAYRNKFGEIREYQQRYGA EIVRRYRAGAGPSPAGDDVT FPEFLRYLVDEDPERMNEHW M |
| Tissue Specificity | Widely expressed. Expressed at high level in pituitary gland, placenta, uterus and thyroid. |
| Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of dermatan sulfate. Plays a pivotal role in the formation of 4-0-sulfated IdoA blocks in dermatan sulfate. Transfers sulfate to the C-4 hydroxyl of beta1,4-linked GalNAc that is substituted with an alpha-linked iduronic acid (IdoUA) at the C-3 hydroxyl. Transfers sulfate more efficiently to GalNAc residues in -IdoUA-GalNAc-IdoUA- than in -GlcUA-GalNAc-GlcUA-sequences. Has preference for partially desulfated dermatan sulfate. Addition of sulfate to GalNAc may occur immediately after epimerization of GlcUA to IdoUA. Appears to have an important role in the formation of the cerebellar neural network during postnatal brain development. |
| Protein Name | Carbohydrate Sulfotransferase 14Dermatan 4-Sulfotransferase 1D4st-1Hd4st1 |
| Database Links | Reactome: R-HSA-2022923Reactome: R-HSA-3595174 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 14 antibodyAnti-Dermatan 4-Sulfotransferase 1 antibodyAnti-D4st-1 antibodyAnti-Hd4st1 antibodyAnti-CHST14 antibodyAnti-D4ST1 antibodyAnti-UNQ1925 antibodyAnti-PRO4400 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
