Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Chromodomain-helicase-DNA-binding protein 1-like (545-594 aa) is suitable for use in Western Blot and ELISA research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-1:2000ELISA 1:20000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CHD1L |
Gene ID: | 9557 |
Uniprot ID: | CHD1L_HUMAN |
Immunogen Region: | 545-594 aa |
Specificity: | CHD1L Polyclonal Antibody detects endogenous levels of CHD1L protein. |
Immunogen: | The antiserum was produced against synthesized peptide derived from the human CHD1L at the amino acid range 545-594 |
Function | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. |
Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1-LikeAmplified In Liver Cancer Protein 1 |
Database Links | Reactome: R-HSA-5696395Reactome: R-HSA-5696400 |
Cellular Localisation | NucleusChromosomeLocalizes At Sites Of Dna DamageRecruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10'Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2 |
Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibodyAnti-Amplified In Liver Cancer Protein 1 antibodyAnti-CHD1L antibodyAnti-ALC1 antibody |
Information sourced from Uniprot.org