Western blot analysis of lysates from HepG2 cells, using CHD1L antibody.

Anti-CHD1L antibody (545-594 aa) (STJ96392)

SKU:
STJ96392
£48.00 - £252.00
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal antibody anti-Chromodomain-helicase-DNA-binding protein 1-like (545-594 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHD1L
Gene ID: 9557
Uniprot ID: CHD1L_HUMAN
Immunogen Region: 545-594 aa
Specificity: CHD1L Polyclonal Antibody detects endogenous levels of CHD1L protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CHD1L at the amino acid range 545-594
Function ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin.
Protein Name Chromodomain-Helicase-Dna-Binding Protein 1-Like
Amplified In Liver Cancer Protein 1
Database Links Reactome: R-HSA-5696395
Reactome: R-HSA-5696400
Cellular Localisation Nucleus
Chromosome
Localizes At Sites Of Dna Damage
Recruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10'
Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2
Alternative Antibody Names Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibody
Anti-Amplified In Liver Cancer Protein 1 antibody
Anti-CHD1L antibody
Anti-ALC1 antibody

Information sourced from Uniprot.org

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