| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHD1L (320-570) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHD1L |
| Gene ID: |
9557 |
| Uniprot ID: |
CHD1L_HUMAN |
| Immunogen Region: |
320-570 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 320-570 of human CHD1L (NP_001243267.1). |
| Immunogen Sequence: |
KLLASEGSTMDEIDLESILG ETKDGQWVSDALPAAEGGSR DQEEGKNHMYLFEGKDYSKE PSKEDRKSFEQLVNLQKTLL EKASQEGRSLRNKGSVLIPG LVEGSTKRKRVLSPEELEDR QKKRQEAAAKRRRLIEEKKR QKEEAEHKKKMAWWESNNYQ SFCLPSEESEPEDLENGEES SAELDYQDPDATSLKYVSGD VTHPQAGAEDALIVHCVDDS GHWGRGGLFTALEKRSAEP |
| Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. |
| Function | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. |
| Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1-LikeAmplified In Liver Cancer Protein 1 |
| Database Links | Reactome: R-HSA-5696395Reactome: R-HSA-5696400 |
| Cellular Localisation | NucleusChromosomeLocalizes At Sites Of Dna DamageRecruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10'Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2 |
| Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibodyAnti-Amplified In Liver Cancer Protein 1 antibodyAnti-CHD1L antibodyAnti-ALC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
