Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | CHD1L |
Gene ID: | 9557 |
Uniprot ID: | CHD1L_HUMAN |
Immunogen Region: | 320-570 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 320-570 of human CHD1L (NP_001243267.1). |
Immunogen Sequence: | KLLASEGSTMDEIDLESILG ETKDGQWVSDALPAAEGGSR DQEEGKNHMYLFEGKDYSKE PSKEDRKSFEQLVNLQKTLL EKASQEGRSLRNKGSVLIPG LVEGSTKRKRVLSPEELEDR QKKRQEAAAKRRRLIEEKKR QKEEAEHKKKMAWWESNNYQ SFCLPSEESEPEDLENGEES SAELDYQDPDATSLKYVSGD VTHPQAGAEDALIVHCVDDS GHWGRGGLFTALEKRSAEP |
Tissue Specificity | Frequently overexpressed in hepatomacellular carcinomas. |
Function | ATP-dependent chromatin remodeler that mediates chromatin-remodeling following DNA damage. Recruited to DNA damage sites through interaction with poly-ADP-ribose: specifically recognizes and binds histones that are poly-ADP-ribosylated on serine residues in response to DNA damage. Poly-ADP-ribose-binding activates the ATP-dependent chromatin remodeler activity, thereby regulating chromatin during DNA repair. Catalyzes nucleosome sliding away from DNA breaks in an ATP-dependent manner. Chromatin remodeling activity promotes PARP2 removal from chromatin. |
Protein Name | Chromodomain-Helicase-Dna-Binding Protein 1-Like Amplified In Liver Cancer Protein 1 |
Database Links | Reactome: R-HSA-5696395 Reactome: R-HSA-5696400 |
Cellular Localisation | Nucleus Chromosome Localizes At Sites Of Dna Damage Recruited By Histones H2b And H3 Poly-Adp-Ribosylated On 'Ser-6' And 'Ser-10' Respectively (H2bs6adpr And H3s10adpr) By Parp1 Or Parp2 |
Alternative Antibody Names | Anti-Chromodomain-Helicase-Dna-Binding Protein 1-Like antibody Anti-Amplified In Liver Cancer Protein 1 antibody Anti-CHD1L antibody Anti-ALC1 antibody |
Information sourced from Uniprot.org