| Tissue Specificity | Widely expressed at low level and at higher level in the lung. Weakly expressed in the heart, lung and kidney. |
| Post Translational Modifications | N-glycosylated. |
| Function | Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation. Required to restrain inflammation in macrophages: production of 25-hydroxycholesterol protects macrophages from cholesterol overload, thereby preventing mitochondrial DNA release and subsequent activation of the AIM2 inflammasome. Interferon-stimulated gene which has broad antiviral activities against a wide range of enveloped viruses. |
| Protein Name | Cholesterol 25-HydroxylaseCholesterol 25-MonooxygenaseM25oh |
| Database Links | Reactome: R-MMU-192105 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cholesterol 25-Hydroxylase antibodyAnti-Cholesterol 25-Monooxygenase antibodyAnti-M25oh antibodyAnti-Ch25h antibody |
Information sourced from Uniprot.org
