| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CERS5 |
| Gene ID: | 91012 |
| Uniprot ID: | CERS5_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CERS5 (NP_001268660.1). |
| Immunogen Sequence: | MMKPRPKRFIAKPCALCIGI EDSGPYQAQPNAILEKVFIS ITKYPDKKRLEGLSKQLDWN VRKIQCWFRHRRNQDKPPTL TKFCESMWRFTFYLCIFCYG |
| Post Translational Modifications | Phosphorylated at the C-terminus by CK2. |
| Function | Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward palmitoyl-CoA (hexadecanoyl-CoA.C16:0-CoA). Can use other acyl donors, but with less efficiency. N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. Plays a role in de novo ceramide synthesis and surfactant homeostasis in pulmonary epithelia. |
| Protein Name | Ceramide Synthase 5 Cers5 Lag1 Longevity Assurance Homolog 5 Sphingoid Base N-Palmitoyltransferase Cers5 Sphingosine N-Acyltransferase Cers5 |
| Database Links | Reactome: R-HSA-1660661 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Ceramide Synthase 5 antibody Anti-Cers5 antibody Anti-Lag1 Longevity Assurance Homolog 5 antibody Anti-Sphingoid Base N-Palmitoyltransferase Cers5 antibody Anti-Sphingosine N-Acyltransferase Cers5 antibody Anti-CERS5 antibody Anti-LASS5 antibody |
Information sourced from Uniprot.org