| Function | Regulatory subunit of the ATP-dependent CERF-1 and CERF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The complexes do not have the ability to slide mononucleosomes to the center of a DNA template. The CERF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the CERF-5 ISWI chromatin remodeling complex. Plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes. In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated. May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis. |
| Protein Name | Chromatin Remodeling Regulator Cecr2Cat Eye Syndrome Critical Region Protein 2 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Chromatin Remodeling Regulator Cecr2 antibodyAnti-Cat Eye Syndrome Critical Region Protein 2 antibodyAnti-CECR2 antibodyAnti-KIAA1740 antibody |
Information sourced from Uniprot.org
