| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CDCP1 (30-343) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CDCP1 |
| Gene ID: |
64866 |
| Uniprot ID: |
CDCP1_HUMAN |
| Immunogen Region: |
30-343 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 30-343 of human CDCP1 (NP_835488.1). |
| Immunogen Sequence: |
FEIALPRESNITVLIKLGTP TLLAKPCYIVISKRHITMLS IKSGERIVFTFSCQSPENHF VIEIQKNIDCMSGPCPFGEV QLQPSTSLLPTLNRTFIWDV KAHKSIGLELQFSIPRLRQI GPGESCPDGVTHSISGRIDA TVVRIGTFCSNGTVSRIKMQ EGVKMALHLPWFHPRNVSGF SIANRSSIKRLCIIESVFEG EGSATLMSANYPEGFPEDEL MTWQFVVPAHLRASVSFLN |
| Tissue Specificity | Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. |
| Post Translational Modifications | Phosphorylated on tyrosine by kinases of the SRC family such as SRC and YES as well as by the protein kinase C gamma/PRKCG. Dephosphorylated by phosphotyrosine phosphatases. Also phosphorylated by suramin, a heparin analog. Tyrosine phosphorylated in response to dissociation of integrin alpha-6 beta-4 from laminin-5. N-glycosylated. A soluble form may also be produced by proteolytic cleavage at the cell surface (shedding). Another peptide of 80 kDa (p80) is present in cultured keratinocytes probably due to tryptic cleavage at an unidentified site on its N-terminal side. Converted to p80 by plasmin, a trypsin-like protease. |
| Function | May be involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. |
| Protein Name | Cub Domain-Containing Protein 1Membrane Glycoprotein Gp140Subtractive Immunization M Plus Hep3-Associated 135 Kda ProteinSima135Transmembrane And Associated With Src KinasesCd Antigen Cd318 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Membrane ProteinShedding May Also Lead To A Soluble PeptideIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Cub Domain-Containing Protein 1 antibodyAnti-Membrane Glycoprotein Gp140 antibodyAnti-Subtractive Immunization M Plus Hep3-Associated 135 Kda Protein antibodyAnti-Sima135 antibodyAnti-Transmembrane And Associated With Src Kinases antibodyAnti-Cd Antigen Cd318 antibodyAnti-CDCP1 antibodyAnti-TRASK antibodyAnti-UNQ2486 antibodyAnti-PRO5773 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
