| Tissue Specificity | Detected on the surface of embryonic epithelial cells in the epidermis, thymus, kidney, intestine, brain choroid plexus, and in retina. Detected in adult and embryonic brain, spleen, kidney, intestine and liver, and in adult testis (at protein level). Observed in all adult tissues tested with strongest expression in kidney, small intestine, spleen, thymus and liver. Moderate expression in brain, stomach, heart, testis, lung, skin, pancreas and skeletal muscle. In brain expressed on capillary endothelia in cerebral cortex. |
| Post Translational Modifications | Phosphorylation on Ser-300 or Ser-302 and on Ser-420 by ecto-protein kinases favors heterotypic cell-cell interactions. N-glycosylated.N-glycosylation is crucial for trafficking and stability of SLC3A2 to the plasma membrane. |
| Function | Acts as a chaperone that facilitates biogenesis and trafficking of functional transporters heterodimers to the plasma membrane. Forms heterodimer with SLC7 family transporters (SLC7A5, SLC7A6, SLC7A7, SLC7A8, SLC7A10 and SLC7A11), a group of amino-acid antiporters. Heterodimers function as amino acids exchangers, the specificity of the substrate depending on the SLC7A subunit. Heterodimers SLC3A2/SLC7A6 or SLC3A2/SLC7A7 mediate the uptake of dibasic amino acids. Heterodimer SLC3A2/SLC7A11 functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane. SLC3A2/SLC7A10 translocates small neutral L- and D-amino acids across the plasma membrane. SLC3A2/SLC75 or SLC3A2/SLC7A8 translocates neutral amino acids with broad specificity, thyroid hormones and L-DOPA. SLC3A2 is essential for plasma membrane localization, stability, and the transport activity of SLC7A5 and SLC7A8. When associated with LAPTM4B, the heterodimer SLC7A5 is recruited to lysosomes to promote leucine uptake into these organelles, and thereby mediates mTORC1 activation. Modulates integrin-related signaling and is essential for integrin-dependent cell spreading, migration and tumor progression. |
| Protein Name | Amino Acid Transporter Heavy Chain Slc3a24f2 Cell-Surface Antigen Heavy Chain4f2hcSolute Carrier Family 3 Member 2Cd Antigen Cd98 |
| Database Links | Reactome: R-MMU-210991Reactome: -MMU-352230Reactome: -MMU-71240 |
| Cellular Localisation | Apical Cell MembraneCell MembraneSingle-Pass Type Ii Membrane ProteinCell JunctionLysosome MembraneMelanosomeBasolateral Cell MembraneLocalized At The Plasma Membrane When Associated With Slc7a5 Or Slc7a8Localized To The Apical Membrane Of Placental Syncytiotrophoblastic CellsRecruited To Lysosomes By Laptm4bLocated Selectively At Cell-Cell Adhesion SitesColocalized With Slc7a8/Lat2 At The Basolateral Membrane Of Kidney Proximal Tubules And Small Intestine EpitheliaExpressed In Both Luminal And Abluminal Membranes Of Brain Capillary Endothelial Cells |
| Alternative Antibody Names | Anti-Amino Acid Transporter Heavy Chain Slc3a2 antibodyAnti-4f2 Cell-Surface Antigen Heavy Chain antibodyAnti-4f2hc antibodyAnti-Solute Carrier Family 3 Member 2 antibodyAnti-Cd Antigen Cd98 antibodyAnti-Slc3a2 antibodyAnti-Mdu1 antibody |
Information sourced from Uniprot.org
