| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CD37 |
| Gene ID: |
951 |
| Uniprot ID: |
CD37_HUMAN |
| Immunogen Region: |
112-241 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 112-241 of human CD37 (NP_001765.1). |
| Immunogen Sequence: |
RAQLERSLRDVVEKTIQKYG TNPEETAAEESWDYVQFQLR CCGWHYPQDWFQVLILRGNG SEAHRVPCSCYNLSATNDST ILDKVILPQLSRLGHLARSR HSADICAVPAESHIYREGCA QGLQKWLHNN |
| Tissue Specificity | B-lymphocytes. Antigen presenting cells. |
| Post Translational Modifications | Tyrosine phosphorylated.leading to activation of downstream signaling pathways. |
| Function | Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Participates thereby in diverse biological functions such as cell signal transduction, adhesion, migration and protein trafficking. Upon ligand binding, two signaling pathways are activated, one acting through phosphorylation by LYN leading to cell death or a survival pathway with activation of GSK3B. Plays an essential role essential for clustering of integrin ITGA4/ITGB1 and promotes its mobility in the plasma membrane of B-cells. In turn, participates in ITGA4/ITGB1 integrin-mediated antiapoptotic signaling through AKT. Plays also a role in the migration of dendritic cells and neutrophils to draining lymph nodes, as well as in their integrin-mediated adhesion. Negatively regulates IL-6 responses through direct interaction with SOCS3 thereby preventing constitutive IL-6 signaling. Alternatively, inhibition of IL-6 signaling can also occur via interaction and stabilization of DECTIN1/CLEC7A at the cell membrane to inhibit its ability to promote the production of IL-6. |
| Protein Name | Leukocyte Antigen Cd37Tetraspanin-26Tspan-26Cd Antigen Cd37 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Antigen Cd37 antibodyAnti-Tetraspanin-26 antibodyAnti-Tspan-26 antibodyAnti-Cd Antigen Cd37 antibodyAnti-CD37 antibodyAnti-TSPAN26 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
