| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Bst2 |
| Gene ID: | 69550 |
| Uniprot ID: | BST2_MOUSE |
| Immunogen Region: | 55-152 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 55-152 of mouse CD317 (NP_932763.1). |
| Immunogen Sequence: | SVACRDGLRAQAECRNTTHL LQRQLTRTQDSLLQAETQAN SCNLTVVTLQESLEKKVSQA LEQQARIKELENEVTKLNQE LENLRIQKETSSTVQVNS |
| Tissue Specificity | In naive mice, specifically expressed on type I interferon-producing cells (at protein level). |
| Function | IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells. Acts as a direct physical tether, holding virions to the cell membrane and linking virions to each other. The tethered virions can be internalized by endocytosis and subsequently degraded or they can remain on the cell surface. In either case, their spread as cell-free virions is restricted. Its target viruses belong to diverse families, including retroviridae: human immunodeficiency virus type 1 (HIV-1), mouse mammary tumor virus (MMTV) and murine leukemia virus (MLV), filoviridae: ebola virus (EBOV), arenaviridae: lassa virus (LASV), and rhabdoviridae: vesicular stomatitis virus (VSV). Can inhibit cell surface proteolytic activity of MMP14 causing decreased activation of MMP15 which results in inhibition of cell growth and migration. Can stimulate signaling by LILRA4/ILT7 and consequently provide negative feedback to the production of IFN by plasmacytoid dendritic cells in response to viral infection. Plays a role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. |
| Protein Name | Bone Marrow Stromal Antigen 2 Bst-2 Hm1.24 Antigen Cd Antigen Cd317 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Golgi Apparatus Trans-Golgi Network Cell Membrane Single-Pass Type Ii Membrane Protein Lipid-Anchor Gpi-Anchor Late Endosome Membrane Raft Cytoplasm Apical Cell Membrane Shuttles Between The Cell Membrane Where It Is Present Predominantly In Membrane/Lipid Rafts And The Trans-Golgi Network Forms A Complex With Mmp14 And Localizes To The Cytoplasm |
| Alternative Antibody Names | Anti-Bone Marrow Stromal Antigen 2 antibody Anti-Bst-2 antibody Anti-Hm1.24 Antigen antibody Anti-Cd Antigen Cd317 antibody Anti-Bst2 antibody |
Information sourced from Uniprot.org