| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Icoslg |
| Gene ID: |
50723 |
| Uniprot ID: |
ICOSL_MOUSE |
| Immunogen Region: |
47-270 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 47-270 of human CD275. (NP_056605.1). |
| Immunogen Sequence: |
ETEVGAMVGSNVVLSCIDPH RRHFNLSGLYVYWQIENPEV SVTYYLPYKSPGINVDSSYK NRGHLSLDSMKQGNFSLYLK NVTPQDTQEFTCRVFMNTAT ELVKILEEVVRLRVAANFST PVISTSDSSNPGQERTYTCM SKNGYPEPNLYWINTTDNSL IDTALQNNTVYLNKLGLYDV ISTLRLPWTSRGDVLCCVEN VALHQNITSISQAESFTGNN TKNP |
| Tissue Specificity | Expressed in lymphoid tissues, primarily in B-cell areas. In the lymph nodes, strongly expressed in the cortex and in both primary and secondary follicles. In other lymphoid tissues, primarily found in the marginal zone of the spleen, the follicles in the Peyer's patches and the medulla of the thymus. Detected on resting splenic T-cells (at protein level). Also expressed in nonlymphoid tissues, such as lung and thymus, as well as, at very low levels, in kidney, liver, peritoneum and testis. Isoform 1: Expressed in brain, heart, spleen, lung, liver skeletal muscle, kidney and testis. Isoform 2: Expressed in heart, spleen and kidney. |
| Function | Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion.induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function (Probable). During pregnancy, may function to skew the cytokine of maternal T-cells toward immunoprotective Th2 phenotype. |
| Protein Name | Icos LigandB7 Homolog 2B7-H2B7-Like Protein Gl50B7-Related Protein 1B7rp-1LicosCd Antigen Cd275 |
| Database Links | Reactome: R-MMU-388841 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 1: Cell MembraneIsoform 2: Cell Membrane |
| Alternative Antibody Names | Anti-Icos Ligand antibodyAnti-B7 Homolog 2 antibodyAnti-B7-H2 antibodyAnti-B7-Like Protein Gl50 antibodyAnti-B7-Related Protein 1 antibodyAnti-B7rp-1 antibodyAnti-Licos antibodyAnti-Cd Antigen Cd275 antibodyAnti-Icoslg antibodyAnti-B7h antibodyAnti-B7h2 antibodyAnti-B7rp1 antibodyAnti-Icosl antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
