Anti-CD136/MST1R/RON nanobody [SAA1369] (STJN000258)

Anti-CD136/MST1R/RON nanobody [SAA1369] (STJN000258)

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STJN000258
£378.50 - £1,632.50
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Host: Alpaca
Applications: ELISA/FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Alpaca monoclonal nanobody anti-Macrophage-Stimulating Protein Receptor is suitable for use in ELISA and Flow Cytometry research applications.
Clonality : Monoclonal
Clone ID : SAA1369
Conjugation: Unconjugated
Isotype: VHH-8His-Cys-tag
Formulation: 0.01M PBS, pH 7.4.
Purification: Purified by Nickel column.
Concentration: 1 mg/mL
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term.
Gene Symbol: MST1R
Gene ID: 4486
Uniprot ID: RON_HUMAN
Post Translational Modifications Proteolytic processing yields the two subunits. Autophosphorylated in response to ligand binding on Tyr-1238 and Tyr-1239 in the kinase domain leading to further phosphorylation of Tyr-1353 and Tyr-1360 in the C-terminal multifunctional docking site. Ubiquitinated. Ubiquitination by CBL regulates the receptor stability and activity through proteasomal degradation. O-mannosylation of IPT/TIG domains on Thr or Ser residues by TMEM260 is required for protein maturation. O-mannosylated residues are composed of single mannose glycans that are not elongated or modified.
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
Protein Name Macrophage-Stimulating Protein Receptor
Msp Receptor
Cdw136
Protein-Tyrosine Kinase 8
P185-Ron
Cd Antigen Cd136 Cleaved Into - Macrophage-Stimulating Protein Receptor Alpha Chain - Macrophage-Stimulating Protein Receptor Beta Chain
Database Links Reactome: R-HSA-8852405
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Nanobody Names Anti-Macrophage-Stimulating Protein Receptor nanobody
Anti-Msp Receptor nanobody
Anti-Cdw136 nanobody
Anti-Protein-Tyrosine Kinase 8 nanobody
Anti-P185-Ron nanobody
Anti-Cd Antigen Cd136 Cleaved Into - Macrophage-Stimulating Protein Receptor Alpha Chain - Macrophage-Stimulating Protein Receptor Beta Chain nanobody
Anti-MST1R nanobody
Anti-PTK8 nanobody
Anti-RON nanobody

Information sourced from Uniprot.org

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