| Function | Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles and pathogens. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration. In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils. May regulate phagocytosis-induced apoptosis in extravasated neutrophils. May play a role in mast cell development. Required with TYROBP/DAP12 in microglia to control production of microglial superoxide ions which promote the neuronal apoptosis that occurs during brain development. |
| Protein Name | Integrin Alpha-MCd11 Antigen-Like Family Member BCr-3 Alpha ChainCell Surface Glycoprotein Mac-1 Subunit AlphaLeukocyte Adhesion Receptor Mo1Neutrophil Adherence ReceptorCd Antigen Cd11b |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-202733Reactome: R-HSA-216083Reactome: R-HSA-6785807Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Nanobody Names | Anti-Integrin Alpha-M nanobodyAnti-Cd11 Antigen-Like Family Member B nanobodyAnti-Cr-3 Alpha Chain nanobodyAnti-Cell Surface Glycoprotein Mac-1 Subunit Alpha nanobodyAnti-Leukocyte Adhesion Receptor Mo1 nanobodyAnti-Neutrophil Adherence Receptor nanobodyAnti-Cd Antigen Cd11b nanobodyAnti-ITGAM nanobodyAnti-CD11B nanobodyAnti-CR3A nanobody |
Information sourced from Uniprot.org
![Anti-CD11b/ITGAM nanobody [SAA1302] (STJN000136)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200749/412931/STJN000136-SDS-PAGE-1__67430.1749232463.jpg?c=1 "Anti-CD11b/ITGAM nanobody [SAA1302] (STJN000136)")
![Anti-CD11b/ITGAM nanobody [SAA1302] (STJN000136)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200749/412931/STJN000136-SDS-PAGE-1__67430.1749232463.jpg?c=1 "Anti-CD11b/ITGAM nanobody [SAA1302] (STJN000136)")
