| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | CCNO |
| Gene ID: | 10309 |
| Uniprot ID: | CCNO_HUMAN |
| Immunogen Region: | 50-150 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CCNO (NP_066970.3). |
| Immunogen Sequence: | PLPGDSGICDLFESPSSGSD GAESPSAARGGSPLPGPAQP VAQLDLQTFRDYGQSCYAFR KAQESHFHPREALARQPQVT AESRCKLLSWLIPVHRQFGL S |
| Tissue Specificity | Present in respiratory cells (at protein level). |
| Function | Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking. |
| Protein Name | Cyclin-O |
| Cellular Localisation | CytoplasmNucleusNucleolusLocalizes To The Apical Part Of Cytoplasm |
| Alternative Antibody Names | Anti-Cyclin-O antibodyAnti-CCNO antibody |
Information sourced from Uniprot.org