| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CCNDBP1 |
| Gene ID: | 23582 |
| Uniprot ID: | CCDB1_HUMAN |
| Immunogen Region: | 1-360 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human CCNDBP1 (NP_036274.3). |
| Immunogen Sequence: | MASATAPAAAVPTLASPLEQ LRHLAEELRLLLPRVRVGEA QETTEEFNREMFWRRLNEAA VTVSREATTLTIVFSQLPLP SPQETQKFCEQVHAAIKAFI AVYYLLPKDQGITLRKLVRG ATLDIVDGMAQLMEVLSVTP TQSPENNDLISYNSVWVACQ QMPQIPRDNKAAALLMLTKN VDFVKDAHEEMEQAVEECDP YSGLLNDTEENNSDNHNHED DVLGFPSNQDLYWSEDDQE |
| Tissue Specificity | Ubiquitously expressed. Expression is down-regulated in a variety of tumor types including breast, colon, prostate and rectal tumors, and is up-regulated in certain hepatic carcinomas. |
| Post Translational Modifications | Phosphorylated. |
| Function | May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F-dependent transcription. |
| Protein Name | Cyclin-D1-Binding Protein 1Grap2 And Cyclin-D-Interacting ProteinHuman Homolog Of Maid |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Cyclin-D1-Binding Protein 1 antibodyAnti-Grap2 And Cyclin-D-Interacting Protein antibodyAnti-Human Homolog Of Maid antibodyAnti-CCNDBP1 antibodyAnti-DIP1 antibodyAnti-GCIP antibodyAnti-HHM antibody |
Information sourced from Uniprot.org