| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CASP5 |
| Gene ID: |
838 |
| Uniprot ID: |
CASP5_HUMAN |
| Specificity: |
Recombinant protein of human Caspase-5. |
| Tissue Specificity | Expressed in barely detectable amounts in most tissues except brain, highest levels being found in lung, liver and skeletal muscle. |
| Post Translational Modifications | The two subunits are derived from the precursor sequence by an autocatalytic mechanism. |
| Function | Thiol protease that acts as a mediator of programmed cell death. Initiates pyroptosis, a programmed lytic cell death pathway through cleavage of Gasdermin-D (GSDMD): cleavage releases the N-terminal gasdermin moiety (Gasdermin-D, N-terminal) that binds to membranes and forms pores, triggering pyroptosis. Also mediates cleavage and maturation of IL18. Cleavage of GSDMD and IL18 is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP4. During non-canonical inflammasome activation, cuts CGAS and may play a role in the regulation of antiviral innate immune activation. |
| Protein Name | Caspase-5Casp-5Ice(Rel-IiiProtease Ich-3Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 |
| Database Links | Reactome: R-HSA-5620971 |
| Alternative Antibody Names | Anti-Caspase-5 antibodyAnti-Casp-5 antibodyAnti-Ice(Rel-Iii antibodyAnti-Protease Ich-3 antibodyAnti-Protease Ty Cleaved Into - Caspase-5 Subunit P20 - Caspase-5 Subunit P10 antibodyAnti-CASP5 antibodyAnti-ICH3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
