• Immunohistochemical analysis of paraffin-embedded Mouse Brain Tissue using CaMKII Beta/Gamma/Delta (Phospho Thr287) Mouse mAb diluted at 1:200.
  • Immunohistochemical analysis of paraffin-embedded Rat Brain Tissue using CaMKII Beta/Gamma/Delta (Phospho Thr287) (mAb diluted at 1:200.

Anti-CaMKI Beta/gamma/delta (Phospho Thr287) antibody (STJ97542)

SKU:
STJ97542
Current Stock:
Host: Mouse
Applications: IHC-P
Reactivity: Human, Rat, Mouse
Short Description: Mouse monoclonal primary antibody against CaMKI Beta/gamma/delta (Phospho Thr287).
Note: FOR RESEARCH USE ONLY (RUO).
Clonality: Monoclonal
Clone ID: 1B9
Conjugation: Unconjugated
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification: The antibody was affinity-purified from mouse ascites by affinity-chromatography using a specific immunogen.
Storage Instruction: Store at-20°C, and avoid repeat freeze-thaw cycles.
Concentration: 1 mg/ml
Isotype: IgG1
Dilution Range: IHC 1:100-200
Specificity: CaMKII beta/gamma/delta (Phospho Thr287) protein detects endogenous levels of CaMKII beta/gamma/delta (Phospho Thr287)
Uniprot ID: KCC2B_HUMAN
Gene ID: 816
Gene Symbol: CAMK2B
Immunogen: Synthetic Peptide
Tissue Specificity Widely expressed. Expressed in adult and fetal brain. Expression is slightly lower in fetal brain. Expressed in skeletal muscle.
Post Translational Modifications Autophosphorylation of Thr-287 following activation by Ca(2+)/calmodulin. Phosphorylation of Thr-287 locks the kinase into an activated state.
Function Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca(2+) transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons. Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
Database Links Reactome: R-HSA-111932
Cellular Localisation Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Sarcoplasmic Reticulum Membrane
Peripheral Membrane Protein
Cytoplasmic Side
Cell Junction
Synapse
In Slow-Twitch Muscle
Evenly Distributed Between Longitudinal Sr And Junctional Sr
Protein Name Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta
Cam Kinase Ii Subunit Beta
Camk-Ii Subunit Beta
Alternative Names Anti-Calcium/Calmodulin-Dependent Protein Kinase Type Ii Subunit Beta antibody
Anti-Cam Kinase Ii Subunit Beta antibody
Anti-Camk-Ii Subunit Beta antibody
Anti-CAMK2B antibody
Anti-CAM2 antibody
Anti-CAMK2 antibody
Anti-CAMKB antibody

Information sourced from Uniprot.org

6 months standard