Anti-C5 antibody (1567-1676) (STJ110403)

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STJ110403
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Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: C5
Gene ID: 727
Uniprot ID: CO5_HUMAN
Immunogen Region: 1567-1676
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 1567-1676 of human C5/C5a (NP_001726.2).
Immunogen Sequence: SITVENVFVKYKATLLDIYK TGEAVAEKDSEITFIKKVTC TNAELVKGRQYLIMGKEALQ IKYNFSFRYIYPLDSLTWIE YWPRDTTCSSCQAFLANLDE FAEDIFLNGC
Function Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. C5a anaphylatoxin: Derived from proteolytic degradation of complement C5, C5a anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
Protein Name Complement C5
C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 4 Cleaved Into - Complement C5 Beta Chain - Complement C5 Alpha Chain - C5a Anaphylatoxin - Complement C5 Alpha' Chain
Database Links Reactome: R-HSA-166665
Reactome: R-HSA-174577
Reactome: R-HSA-375276
Reactome: R-HSA-418594
Reactome: R-HSA-977606
Cellular Localisation Secreted
Alternative Antibody Names Anti-Complement C5 antibody
Anti-C3 And Pzp-Like Alpha-2-Macroglobulin Domain-Containing Protein 4 Cleaved Into - Complement C5 Beta Chain - Complement C5 Alpha Chain - C5a Anaphylatoxin - Complement C5 Alpha' Chain antibody
Anti-C5 antibody
Anti-CPAMD4 antibody

Information sourced from Uniprot.org