Anti-BPTF antibody [2F10] (STJ97882)

Anti-BPTF antibody [2F10] (STJ97882)

SKU:
STJ97882
£144.00 - £348.00
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Covered by St John's Laboratory Guarantee

Host: Mouse
Applications: WB/ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Nucleosome-remodeling factor subunit BPTF is suitable for use in Western Blot and ELISA research applications.
Clonality : Monoclonal
Clone ID : 2F10
Conjugation: Unconjugated
Isotype: IgG2b
Formulation: Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: BPTF
Gene ID: 2186
Uniprot ID: BPTF_HUMAN
Specificity: BPTF Monoclonal Antibody detects endogenous levels of BPTF protein.
Immunogen: Purified recombinant fragment of human BPTF expressed in E. Coli.
Post Translational Modifications Phosphorylation enhances DNA-binding. Highly susceptible to proteolysis.
Function Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors.
Protein Name Nucleosome-Remodeling Factor Subunit Bptf
Bromodomain And Phd Finger-Containing Transcription Factor
Fetal Alz-50 Clone 1 Protein
Fetal Alzheimer Antigen
Cellular Localisation Cytoplasm
Nucleus
Localizes To Sites Of Dna Damage
In Brains Of Alzheimer Disease Patients
Present In A Subset Of Amyloid-Containing Plaques
Alternative Antibody Names Anti-Nucleosome-Remodeling Factor Subunit Bptf antibody
Anti-Bromodomain And Phd Finger-Containing Transcription Factor antibody
Anti-Fetal Alz-50 Clone 1 Protein antibody
Anti-Fetal Alzheimer Antigen antibody
Anti-BPTF antibody
Anti-FAC1 antibody
Anti-FALZ antibody

Information sourced from Uniprot.org

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