| Host: |
Mouse |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Nucleosome-remodeling factor subunit BPTF is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
2F10 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2b |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
BPTF |
| Gene ID: |
2186 |
| Uniprot ID: |
BPTF_HUMAN |
| Specificity: |
BPTF Monoclonal Antibody detects endogenous levels of BPTF protein. |
| Immunogen: |
Purified recombinant fragment of human BPTF expressed in E. Coli. |
| Post Translational Modifications | Phosphorylation enhances DNA-binding. Highly susceptible to proteolysis. |
| Function | Regulatory subunit of the ATP-dependent NURF-1 and NURF-5 ISWI chromatin remodeling complexes, which form ordered nucleosome arrays on chromatin and facilitate access to DNA during DNA-templated processes such as DNA replication, transcription, and repair. The NURF-1 ISWI chromatin remodeling complex has a lower ATP hydrolysis rate than the NURF-5 ISWI chromatin remodeling complex. Within the NURF-1 ISWI chromatin-remodeling complex, binds to the promoters of En1 and En2 to positively regulate their expression and promote brain development. Histone-binding protein which binds to H3 tails trimethylated on 'Lys-4' (H3K4me3), which mark transcription start sites of active genes. Binds to histone H3 tails dimethylated on 'Lys-4' (H3K4Me2) to a lesser extent. May also regulate transcription through direct binding to DNA or transcription factors. |
| Protein Name | Nucleosome-Remodeling Factor Subunit BptfBromodomain And Phd Finger-Containing Transcription FactorFetal Alz-50 Clone 1 ProteinFetal Alzheimer Antigen |
| Cellular Localisation | CytoplasmNucleusLocalizes To Sites Of Dna DamageIn Brains Of Alzheimer Disease PatientsPresent In A Subset Of Amyloid-Containing Plaques |
| Alternative Antibody Names | Anti-Nucleosome-Remodeling Factor Subunit Bptf antibodyAnti-Bromodomain And Phd Finger-Containing Transcription Factor antibodyAnti-Fetal Alz-50 Clone 1 Protein antibodyAnti-Fetal Alzheimer Antigen antibodyAnti-BPTF antibodyAnti-FAC1 antibodyAnti-FALZ antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
