| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:100-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | BLVRA |
| Gene ID: | 644 |
| Uniprot ID: | BIEA_HUMAN |
| Immunogen Region: | 1-296 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-296 of human BLVRA (NP_001240752.1). |
| Immunogen Sequence: | MNAEPERKFGVVVVGVGRAG SVRMRDLRNPHPSSAFLNLI GFVSRRELGSIDGVQQISLE DALSSQEVEVAYICSESSSH EDYIRQFLNAGKHVLVEYPM TLSLAAAQELWELAEQKGKV LHEEHVELLMEEFAFLKKEV VGKDLLKGSLLFTAGPLEEE RFGFPAFSGISRLTWLVSLF GELSLVSATLEERKEDQYMK MTVCLETEKKSPLSWIEEKG PGLKRNRYLSFHFKSGSLE |
| Tissue Specificity | Liver. |
| Function | Reduces the gamma-methene bridge of the open tetrapyrrole, biliverdin IXalpha, to bilirubin with the concomitant oxidation of a NADH or NADPH cofactor. Does not reduce bilirubin IXbeta. Uses the reactants NADH or NADPH depending on the pH.NADH is used at the acidic pH range (6-6.9) and NADPH at the alkaline range (8.5-8.7). NADPH, however, is the probable reactant in biological systems. |
| Protein Name | Biliverdin Reductase ABvr ABiliverdin-Ix Alpha-Reductase |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-9707564 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Biliverdin Reductase A antibodyAnti-Bvr A antibodyAnti-Biliverdin-Ix Alpha-Reductase antibodyAnti-BLVRA antibodyAnti-BLVR antibodyAnti-BVR antibody |
Information sourced from Uniprot.org